. 2020 Sep 29;11(20):3214–3232. doi: 10.1021/acschemneuro.0c00304

Table 3. Competition of 20a–d and 21a–d Compounds of [³H]-WIN 35,428 Binding to Rabbit Striatal Membranes, [³H]Nisoxetine, and [³H]Paroxetine Binding to Rabbit Cortical Membranes.

compound^b	[³H]-WIN 35,428, K_i^a (nM)	[³H]nisoxetine, K_i^a (nM)	[³H]paroxetine, K_i^a (nM)
20a	>100,000	520	1.68 ± 0.49
20b	>100,000^c	10,000	0.027 ± 0.005^c
20c	>100,000	400	32.55 ± 12.56
20d	>100,000^c	1,740	0.034 ± 0.0098^c
21a	>100,000	>10,000	14.13 ± 3.04
21b	>100,000^c	>10,000	0.316 ± 0.101^c
21c	11,100 ± 4,900	2,070	50.02 ± 18.93
21d	11,200 ± 2,700^c	2,450	0.250 ± 0.07^c
paroxetine^d	769^e	80 ± 1	0.31 ± 0.018

The K_i values are expressed as the mean ± SE of three or more independent experiments.

Prepared and tested as hydrochloride salts.

Reference (21).

Reference (29).

The K_i value represents the average of two independent experiments.

Table 3. Competition of 20a–d and 21a–d Compounds of [3H]-WIN 35,428 Binding to Rabbit Striatal Membranes, [3H]Nisoxetine, and [3H]Paroxetine Binding to Rabbit Cortical Membranes.