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. 2021 Mar 22;148(6):dev196964. doi: 10.1242/dev.196964

Fig. 4.

Fig. 4.

Differential expression of clustered protocadherins during β-cell development. (A) Expression levels of representative clustered protocadherins show that the cluster γ protocadherin Pcdhgc5 is preferentially expressed at earlier stages of pancreas development (E8.0 Sox17+-E9.5 Pdx1+), whereas cluster β protocadherin Pcdhb16 is preferentially expressed in E15.5 endocrine cell populations, and the cluster α protocadherin Pcdha11 is preferentially expressed in mature β-cells at P60. (B) Immunofluorescence staining confirms preferential expression of PCDHGC5 protein in Pdx1.CFP-marked pancreatic progenitor cells at E9.5, PCDHB16 expression in Insm1.GFP-marked endocrine progenitor cells at E15.5, and preferential expression of PCDH11 in insulin-positive adult β-cells at P60. Scale bar: 50 µm.