Fig. 5.
Distribution of zinc finger proteins (ZFPs) in β-cell development GCN. (A) A meta-network view of GCN shows module nodes colored according to the proportion of ZFP-coding genes in the modules. Genes coding for ZFPs are enriched in meta-module J (endocrine specification). The C2H2-type ZFPs within each developmental module were identified via GO analysis. Quantified enrichments are represented as a percentage of C2H2 ZPF coding genes per total number of genes within a given module. Thick blue outlines indicate modules that contain the three ZFPs selected for further analysis: Zfp800, Jazf1 and Zfp92. (B) Expression levels of Zfp800, Jazf1 and Zfp92 in profiled developmental lineages show that Zfp800 is preferentially expressed in pancreatic multipotent and endocrine progenitor cells, Jazf1 in endocrine progenitors and nascent β-cells, and Zfp92 in nascent and mature β-cells.