Fig. 4.

QoL and PROs. The absolute change in IBDQ (a) and CDAI (c) is shown as mean with SD and was statistically significant for all visits (months 3–24) compared to BL (month 0). The mean change for each of the 4 domains of the IBDQ is presented in (b) revealing statistically significant changes for all items in months 3 and 24 in comparison to BL. Analyses were done for the mITT analysis set, and p values were generated using the Wilcoxon signed-rank test (*) or paired t test (*¹). n, number of patients with available data for the respective time point. QoL, quality of life; PRO, patient-reported outcome; IBDQ, inflammatory bowel disease questionnaire; CDAI, Crohn's disease activity index; BL, baseline; mITT, modified intention to treat.