Fig. 5.

Disease-related HCRU. Disease-related HCRU were assessed by the number of physician (black bars) and non-physician (blank bars) visits over the 3-month period as indicated. Alternative services or out-patient visits were counted among non-physician visits. HCRUs documented with start of utilization at most 90 days prior to BL visit (month 0) were defined as “before BL.” For post-BL periods, the start date of any HCRU is allocated to the respective visit period. The numbers of HCRUs with date 90 days prior to the date of the respective visit are used, regardless of the exact duration between the visits and the start date of the HCRU. n, number of patients with available data for the respective time point; nd, no visits were documented (number of visits = 0); HCRU, health-care resource utilization; BL, baseline.