Fig. 3.

Neuropathologic findings.

A Coronal section of the right cerebral hemisphere containing multiple acute microinfarcts and focal region suggestive of a thrombosed and hemorrhagic blood vessel (arrow). B Histological confirmation of an acute infarct with scattered microhemorrhages and associated microthrombi (arrowheads). Insets: two additional identified microthrombi (arrowheads) (H&E, ×400). C Subacute microinfarct with foamy macrophages (H&E, ×100). D Acute ischemic infarct associated with mildly hyperplastic and congested blood vessels (H&E, ×400). E Blood vessels are highlighted by CD34 (×400). F Area of microhemorrhage with associated reactive changes within the basal ganglia (LFB, ×400). G Immunohistochemical staining highlights ACE2 expression within many cerebral blood vessels (ACE2, ×100, arrows). H Coronal section at the level of the genu of the corpus callosum showing areas of hemorrhage and myelin loss. I Histology of the corpus callosum lesions, demonstrating small areas of perivascular myelin loss, highlighted by luxol fast blue stain (LFB), rarely associated with hemorrhage (×400).