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. Author manuscript; available in PMC: 2021 Nov 21.
Published in final edited form as: Lancet. 2020 Nov 10;396(10263):1637–1643. doi: 10.1016/S0140-6736(20)32332-1

Figure 1: Effect of LDL cholesterol lowering on the risk of major vascular events with statin and non-statin treatment in older patients.

Figure 1:

Older patients were aged 75 years or older. RRs per 1 mmol/L reduction in LDL cholesterol were generated from a random effects model. In the ODYSSEY OUTCOMES trial, the event numbers were provided at 4 years, whereas the RR is for the entire duration of trial. CTTC=Cholesterol Treatment Trialists’ Collaboration. EWTOPIA 75=Ezetimibe Lipid-Lowering Trial on Prevention of Atherosclerosclerotic Disease in 75 or Older. FOURIER=Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Patients with Elevated Risk. IMPROVE-IT=Improved Reduction of Outcomes: Vytorin Efficacy International Trial. ODYSSEY OUTCOMES=Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment with Alirocumab. RR=risk ratio.