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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Med Sci Sports Exerc. 2020 Jul;52(7):1456–1469. doi: 10.1249/MSS.0000000000002294

Figure 2. Treadmill exercise training improve fear-avoidance behavior in TgF344-AD rats.

Figure 2.

(A) The passive avoidance task was performed to test fear-avoidance behavior. (a) Schematic diagram of the passive avoidance test apparatus. (b) Latency to enter the dark box during the training phase and test phase was recorded and analyzed. (B) Representative tracking plots of rats on the training days (a-c) and probe trial day (e-g). Escape latency (d) and quadrant occupancy (h) were recorded and statistically analyzed. (C) The novel object test and object location test were performed to assess recognition memory and spatial cognitive ability. (a-c) Representative occupancy plots of animals’ exploration of the novel object (red) and the familiar object (yellow) in the novel object test (a-c). The time spent on exploring each object and the discrimination index percentage were analyzed (d). The representative occupancy plots and discrimination index of animals in object location test are shown in (e-h). All data are presented as mean ± SEM (n= 8–12). *P < 0.05 vs WT group, #P < 0.05 vs AD group. N.S., no significant difference.