In vitro cytotoxicity assay against osteosarcoma (MG-63) cells using curcumin-, vitamin K2-, and curcumin + vitamin K2-loaded HA-coated Ti implants at days 3, 7, and 11. (a) MTT assay showing the effects of curcumin, vitamin K2, and curcumin + vitamin K2 on osteosarcoma cell viability (* denotes p ≤ 0.001, ** denotes p ≤ 0.05). (b) Morphological characterization by FESEM showing the osteosarcoma cell attachment and proliferation on curcumin-, vitamin K2-, and curcumin + vitamin K2-loaded HA-coated Ti implant surface.