Table 2.
Seed-to-voxel functional connectivity clusters at baseline associated with symptom improvement after treatment from Philip et al. (Philip et al., 2018).
| Scale | Seed-to-Cluster Pair | Peak MNI Coordinate | Cluster Size |
Cluster p-FDR |
|---|---|---|---|---|
| PCL | L. Amygdala-L. MPFC | −20 +54 +16 | 723 | <.001 |
| R. Amygdala-L. MPFC | −14 +60 +10 | 363 | <.001 | |
| R. Amygdala-VMPFC | −16 +22 –8 | 226 | <.001 | |
| R. sgACC-R. Lat. PFC | 16 +2 +58 | 151 | <.005 | |
| R. sgACC-L. Lat. PFC | −20 +8 +54 | 143 | <.005 | |
| IDSSR | L. Amygdala-L. MPFC | −22 +54 +16 | 349 | <.001 |
| L. Amygdala-L. DLPFC | −26 +30 +46 | 60 | <.001 | |
| R. Amygdala-L. MPFC | −14 +62 –12 | 138 | <.001 | |
Abbreviations: MNI, Montreal neurological institute; FDR, false-discovery rate; L, left; R, right; MPFC, medial prefrontal cortex; PCL, PTSD checklist for DSM-5; IDSSR, inventory of depressive symptomatology, self-report; DLPFC, dorsolateral prefrontal cortex; VMPFC, ventromedial prefrontal cortex; Lat, lateral; PFC, prefrontal cortex