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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Immunol Rev. 2020 Apr 1;295(1):101–113. doi: 10.1111/imr.12853

Figure 3: Obese ATM have a unique hypermetabolic phenotype.

Figure 3:

A) Metabolic pathways are well-defined in BMDM polarized to M1 and M2 macrophages in vitro. B) Lean ATMs have low metabolic utilization, and may have multiple populations that handle catecholamines, iron, and lipids. In contrast, obese ATMs are hypermetabolic. Recent single cell RNA-sequencing data suggests that obese ATM also have multiple mixed populations. Future work should define 1) if the hypermetabolic phenotype is a result of pooled populations or if it is present in single populations and 2) how obese ATMs use glycolysis and OX PHOS for energy production, intermediate mediators, and both phagocytic and inflammatory functions.