Table 1.
Populations of adipose tissue macrophages identified by single cell RNA sequencing
| Citation | Mouse or Human | Populations | Function/ Role | Obesity Phenotype | Associated genes/ Other info |
|---|---|---|---|---|---|
| 37 | Both | Cd11b+Ly6c+ | monocyte derived cells | Increased | |
| CD11b+Ly6C−F480+ CD64+ CD9− | interstitially spaced, vascular development/organization | No difference | |||
| CD11b+Ly6C−F480+ CD64+ CD9+ | surrounding CLS, lipid metabolism | Increased | -Lpl, Plin2, CD63, ACp5, Ctss, Lamp2, Lipa, IL1ra, IL18, Tnf, Ccl2 | ||
| 39 | Mouse | Lyve lo MHCII hi | nerve associated macs | Unknown | |
| Lyve hi MHC II lo | vascular associated macs | Unknown | |||
| 38 | Mouse | “Mon1” | Decreased | -Retnla, Fn1 | |
| “Mon2” | Decreased | -Plac8, Clec4e | |||
| “Mac1” | Decreased | -Retnla, Lyve1, CD209f, Cd163 -associated with perivascular macrophages from Chakarov 2019 [ref 39] | |||
| “Mac 2” | surrounding CLS | Increased | -Nche1, Cd9 | ||
| “Mac 3” | surrounding CLS, lipid metabolism/ phagocytosis (LAMs) | Increased | -Nche1, Cd9, Spp1, Trem2, Lipa, Lpl, Ctsb, Ctsl, Fabp5, Fabp5, Lgals1/3, Cd36 -associated with CD9+ from Hill 2018 [ref 37] -KO Trem2 increased weight, body fat, glucose intolerance, insulin, cholesterol, LDL |