Table 1. . Base line characteristics of patients.
Primary site of tumor | Age (years)/sex | Mutation | Response to imatinib | Response to sunitinib | Response to regorafenib | Other treatments tried | Sites of metastasis | |
---|---|---|---|---|---|---|---|---|
A | Jejunum | 28/male | c-KIT exon 17 | PR | PD | PD | Progressed on immunotherapy | Liver, omental, serosa |
B | Duodenum | 49/male | c-KIT exon 11 | PR | PD | PD | Progressed on immunotherapy | Liver, omental, serosa, bone, nodes |
C | Stomach | 40/male | c-KIT exon 9 | PR | PD | PR | Liver, omental, bone | |
D | Duodenum | 60/female | Not known | PR | PD | PD | Progressed on pazopanib | Liver, omental, serosa |
E | Stomach | 76/male | PDGFRA D842V | PD | Could not tolerate | PR | Liver, serosa |
PD: Progressive disease; PDGFRA: Platelet-derived growth factor alpha; PR: Partial response; SD: Stable disease.