Table 2:
Multivariable Analysis of Relapse and Non-Relapse Mortality
| Variables | Number | Relapse | Non-Relapse Mortality | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Main effect | <0.001 | <0.001 | |||
| RIC-L/I-Risk vs MAC-L/I-Risk: | 999/1539 | 1.54 (1.35–1.76) | <0.001 | 0.74 (0.62–0.88) | <0.001 |
| RIC-High-Risk vs MAC-High-Risk: | 728/1121 | 1.23 (1.08–1.41) | 0.0019 | 0.83(0.68–1.00) | 0.0510 |
| MAC-High-Risk vs MAC-L/I-Risk: | 1121/1539 | 1.89 (1.67–2.13) | <0.001 | 1.06 (0.91–1.24) | 0.453 |
| RIC-High-Risk vs RIC-L/I-Risk: | 728/999 | 1.51 (1.31–1.74) | <0.001 | 1.18(0.97–1.44) | 0.0966 |
| Age, years | 0.0002 | ||||
| 40–50 | 1214 | - | - | 1.00 | |
| 51–60 | 2176 | - | - | 1.24 (1.07–1.44) | 0.0040 |
| 61–65 | 997 | - | - | 1.45 (1.21–1.75) | <0.001 |
| Donor | <0.001 | <.0001 | |||
| HLA identical Sibling | 1309 | 1.00 | 1.00 | ||
| Mismatched relative (≥7/8) / Other relatives (missing HLA) | 314 | 0.81 (0.67–0.98) | 0.027 | 1.24 (0.93–1.65) | 0.14 |
| Matched unrelated donor (8/8) | 1754 | 0.79 (0.70–0.88) | <0.001 | 1.41 (1.21–1.65) | <0.001 |
| Unrelated (≤7/8) and matching unknown | 412 | 0.74 (0.62–0.88) | <0.001 | 2.02 (1.64–2.49) | <0.001 |
| Umbilical cord blood | 598 | 0.76 (0.65–0.89) | <0.001 | 2.18 (1.79–2.64) | <0.001 |
| HCT-CI | <.0001 | ||||
| 0 | 930 | - | - | 1.00 | |
| 1 | 628 | - | - | 1.02 (0.82–1.26) | 0.87 |
| 2 | 604 | - | - | 1.06 (0.86–1.31) | 0.60 |
| ≥3 | 2191 | - | - | 1.34 (1.15–1.57) | <0.001 |
| Missing | 34 | - | - | 0.66 (0.29–1.48) | 0.31 |
| Year of Transplant | <.0001 | ||||
| 2009–2012 | 2208 | - | - | 1.35 (1.20–1.53) | <0.001 |
| 2013–2015 | 2179 | - | - | 1.00 | |
HR, hazard ratio. RIC, reduced-intensity conditioning. MAC, myeloablative conditioning. L/I, low/intermediate risk disease risk index (DRI). High-risk, high/very high risk DRI. HCT-CI, hematopoietic cell transplant comorbidity index.