Table 3:
Multivariable Analysis of Disease-Free and Overall Survival
| Variables | Number | Disease-Free Survival | Overall Survival | ||
|---|---|---|---|---|---|
| HR 95% CI) | P value | HR (95%CI) | P value | ||
| Main effect | <0.001 | <0.001 | |||
| RIC-L/I-Risk vs MAC-L/I-Risk: | 999/1539 | 1.19 (1.07–1.33) | 0.0012 | 1.11 (0.99–1.25) | 0.0611 |
| RIC-High-Risk vs MAC-High-Risk: | 728/1121 | 1.07 (0.96–1.19) | 0.240 | 1.00 (0.90–1.12) | 0.978 |
| MAC-High-Risk vs MAC-L/I-Risk: | 1121/1539 | 1.82 (1.65–2.00) | <0.001 | 1.77 (1.61–1.96) | <0.001 |
| RIC-High-Risk vs RIC-L/I-Risk: | 728/999 | 1.63 (1.45–1.83) | <0.001 | 1.60 (1.42–1.80) | <0.001 |
| Donor | 0.0041 | <.0001 | |||
| HLA identical Sibling | 1309 | 1.00 | 1.00 | ||
| Mismatched relative (≥7/8) / Other relatives (missing HLA) | 314 | 0.96 (0.80–1.17) | 0.70 | 0.98 (0.83–1.17) | 0.85 |
| Matched unrelated donor (8/8) | 1754 | 0.96 (0.88–1.06) | 0.44 | 0.99 (0.90–1.10) | 0.91 |
| Unrelated (≤7/8) and matching unknown | 412 | 1.11 (0.97–1.27) | 0.14 | 1.26 (1.09–1.45) | 0.0014 |
| Umbilical cord blood | 598 | 1.20 (1.06–1.37) | 0.0041 | 1.49 (1.32–1.69) | <0.001 |
| Karnofsky Score | <.0001 | <.0001 | |||
| <90 | 1788 | 1.00 | 1.00 | ||
| ≥90 | 2530 | 0.79 (0.74–0.86) | <0.001 | 0.76 (0.70–0.82) | <0.001 |
| Missing | 69 | 0.97 (0.73–1.29) | 0.83 | 1.08 (0.81–1.45) | 0.59 |
| HCT-CI | <.0001 | <.0001 | |||
| 0 | 930 | 1.00 | 1.00 | ||
| 1 | 628 | 1.08 (0.95–1.23) | 0.25 | 1.09 (0.95–1.25) | 0.20 |
| 2 | 604 | 1.07 (0.94–1.22) | 0.28 | 1.14 (0.99–1.30) | 0.065 |
| ≥3 | 2191 | 1.24 (1.13–1.37) | <0.001 | 1.35 (1.22–1.50) | <0.001 |
| Missing | 34 | 1.40 (0.87–2.23) | 0.17 | 1.21 (0.80–1.83) | 0.36 |
| GVHD prophylaxis | 0.0157 | ||||
| TCD/CD34 | 122 | 1.00 | - | - | |
| Tac + MMF/MTX +/− others | 3348 | 0.95 (0.76–1.20) | 0.67 | - | - |
| CSA + MMF/MTX +/− others | 602 | 1.15 (0.90–1.46) | 0.26 | - | - |
| Post-cy + others | 206 | 1.02 (0.76–1.38) | 0.88 | - | - |
| Others/Missing | 109 | 1.15 (0.84–1.57) | 0.39 | - | - |
| ATG/Alemtuzumab | 0.0011 | 0.0053 | |||
| Yes | 1172 | 1.00 | 1.00 | ||
| No | 3207 | 0.86 (0.79–0.94) | <0.001 | 0.88 (0.80–0.96) | 0.0049 |
| Missing | 8 | 0.36 (0.11–1.15) | 0.085 | 0.30 (0.07–1.19) | 0.086 |
| Year of transplant | 0.0204 | 0.0003 | |||
| 2013–2015 | 2179 | 1.00 | 1.00 | ||
| 2009–2012 | 2208 | 1.10 (1.01–1.18) | 0.020 | 1.16 (1.07–1.26) | <0.001 |
GVHD, graft-versus-host disease. IPS, idiopathic pulmonary syndrome. ARDS, acute respiratory distress syndrome.