Overview of frequently mutated epigenetic modifiers. This includes (1) DNA cytosine modifications DNMT3A, TET2, and IDH1/2; (2) histone post-translational modifications ASXL1, BCOR/L1, and MLL1(KMT2A); and (3) Cohesin complex SMC1A, SMC3, and RAD21, bound to STAG1/2. Mutated genes are highlighted with a red star. (Refer to the main text for detailed explanations of the depicted processes.) (Figure reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2019–2020. All rights reserved.)