. 2021 Mar 18;12:601752. doi: 10.3389/fendo.2021.601752

Table 1.

Characteristics of 1998 women.

Characteristics	NOR	pre-POI	Early POI	POF	P	P-adj ⁱ
N	987	410	147	454	–	–
Age at diagnosis (y) ^d ^, ^e	–	32.38 ± 4.07	30.22 ± 3.72	29.55 ± 4.19	<0.001 ^g	–
BMI (kg/m²) ^f	22.81 ± 3.24	22.84 ± 3.43	23.30 ± 3.50	22.44 ± 3.20	0.040 ^g	–
Age at menarche (y) ^c ^, ^e , ^f	14.07 ± 1.46	14.08 ± 1.84	14.25 ± 2.05	14.92 ± 2.57	<0.001 ^g	–
Age at irregularity (y) ^e	–	23.65 ± 7.38	21.52 ± 5.71	21.70 ± 5.89	0.007 ^g	–
Age at amenorrhea (y)	–	–	22.59 ± 5.67	23.24 ± 5.82	0.417 ^g	–
FSH (IU/L) ^a ^, ^b ^, ^c ^, ^d ^, ^e ^, ^f	6.81 ± 1.17	14.90 ± 4.23	31.73 ± 4.35	70.77 ± 23.11	<0.001 ^g	<0.001
LH (IU/L) ^a ^, ^b ^, ^c ^, ^d ^, ^e ^, ^f	4.63 ± 1.70	6.53 ± 3.23	16.37 ± 8.28	35.65 ± 13.90	<0.001 ^g	<0.001
FSH/LH Ratio ^a ^, ^b ^, ^c ^, ^e ^, ^f	1.64 ± 0.66	2.49 ± 1.22	2.37 ± 1.14	2.14 ± 0.84	<0.001 ^g	<0.001
PRL (ng/mL)	14.32 (10.15, 20.00)	13.59 (9.90, 19.50)	11.41 (7.75, 15.90)	9.95 (7.39, 14.52)	<0.001 ^h	0.268
E₂ (pg/mL) ^b ^, ^c ^, ^d ^, ^e ^, ^f	34.30 (25.30, 44.90)	30.20 (19.50, 45.28)	15.65 (5.23, 31.60)	7.15 (5.00, 20.54)	<0.001 ^h	<0.001
T (ng/dL) ^b ^, ^c ^, ^e	21.18 ± 9.67	20.55 ± 11.38	18.39 ± 12.16	18.14 ± 13.00	<0.001 ^g	0.002
AMH (ng/mL) ^a ^, ^b ^, ^c ^, ^d ^, ^e	2.513 (1.817, 3.491)	0.424 (0.091, 1.024)	0.078 (0.071, 0.091)	0.078 (0.071, 0.087)	<0.001 ^h	<0.001
Inhibin B (pg/mL) ^a ^, ^b ^, ^c ^, ^d ^, ^e	65.18 (45.04, 87.89)	37.05 (14.30, 65.07)	13.00 (10.00, 15.50)	13.30 (10.00, 16.00)	<0.001 ^h	<0.001
AFC ^a ^, ^b ^, ^c ^, ^d ^, ^e	8 (6, 14)	4 (1, 6)	0 (0, 2)	0 (0, 1)	<0.001 ^h	<0.001

Data are expressed as the mean ± standard deviation or median (interquartile range).

BMI, body mass index; FSH, follicle-stimulating hormone; LH, luteinizing hormone; E₂, estradiol; PRL, prolactin; T, testosterone; AMH, anti-müllerian hormone; AFC, antral follicle count.

P<0.05 for the comparison between NOR and pre-POI.

P<0.05 for the comparison between NOR and early POI.

P<0.05 for the comparison between NOR and POF.

P<0.05 for the comparison between pre-POI and early POI.

P<0.05 for the comparison between pre-POI and POF.

P<0.05 for the comparison between early POI and POF.

One-way analysis of variance.

Kruskal-Wallis ANOVA test.

ⁱ

Adjusted P‐value after correcting for age and BMI through multiple logistic regression.