Table 4.

Characteristics of POI patients within different etiologies.

Characteristics	Genetic (n=61)	Iatrogenic (n=35)	Autoimmune (n=102)	Idiopathic (n=403)	P
Age at diagnosis (y)	29.16 ± 4.22	30.11 ± 3.79	29.90 ± 4.30	29.71 ± 4.05	0.648 f
BMI (kg/m2)	22.30 ± 2.98	21.88 ± 2.65	22.52 ± 2.98	22.80 ± 3.46	0.327 f
Age at menarche (y) a , c , d , e	15.95 ± 3.34	13.40 ± 1.56	14.81 ± 2.84	14.68 ± 2.19	<0.001 f
Age at irregularity (y)	21.18 ± 5.28	24.41 ± 5.24	21.63 ± 6.30	21.54 ± 5.83	0.056 f
Age at amenorrhea (y)	22.14 ± 5.08	25.11 ± 5.35	23.02 ± 6.23	23.12 ± 5.80	0.186 f
FSH (IU/L)	63.14 ± 26.66	59.82 ± 32.99	59.43 ± 23.35	62.21 ± 27.71	0.756 f
LH (IU/L)	30.28 ± 15.91	33.53 ± 23.43	30.59 ± 15.52	31.99 ± 16.22	0.762 f
PRL (ng/mL)	11.26 (7.94, 16.54)	11.23 (7.86, 18.30)	10.84 (7.07, 15.12)	9.90 (7.56, 14.16)	0.240 g
E2 (pg/mL)	9.08 (5.00, 23.90)	12.35 (6.53, 24.78)	11.50 (5.00, 28.25)	9.00 (5.00, 23.15)	0.419 g
T (ng/dL)	18.76 ± 14.50	17.35 ± 13.55	17.53 ± 13.11	20.36 ± 16.03	0.353 f
AMH (ng/mL) a , d	0.076 (0.072, 0.083)	0.080 (0.076, 0.33)	0.078 (0.069, 0.083)	0.079 (0.071, 0.090)	0.011 g
Inhibin B (pg/mL) a , b , c	10 (10, 13.69)	14 (10, 16.6)	14 (10, 16.20)	13.5 (10, 16)	0.003 g
AFC a , c	0 (0, 0)	1 (0, 2)	0 (0, 1)	0 (0, 1)	<0.001 g

Data are expressed as the mean ± standard deviation or median (interquartile range).

BMI, body mass index; FSH, follicle-stimulating hormone; LH, luteinizing hormone; E₂, estradiol; PRL, prolactin; T, testosterone; AMH, anti-müllerian.

Hormone; AFC, antral follicle count.

^aP < 0.05 for the comparison between genetic POI and iatrogenic POI.

^bP < 0.05 for the comparison between genetic POI and autoimmune POI.

^cP < 0.05 for the comparison between genetic POI and idiopathic POI.

^dP < 0.05 for the comparison between iatrogenic POI and autoimmune POI.

^eP < 0.05 for the comparison between iatrogenic POI and idiopathic POI.

^fOne-way analysis of variance.

^gKruskal-Wallis ANOVA test.