Table 1.
Demographic and historical features.
| OVERALL | ET | ET PLUS | ET-PD | P (ALL) | ADJ. P (ET VS ET PLUS) | ADJ. P (ET VS ET-PD) | ADJ. P (ET PLUS VS ET-PD) | |
|---|---|---|---|---|---|---|---|---|
| Tremor Classification | ||||||||
| Number of patients (%) | 300 (100%) | 62 (20.7%) | 160 (53.3%) | 78 (26.0%) | ||||
| Gender | ||||||||
| Male | 157 (52.3%) | 36 (58.1%) | 70 (43.8%) | 51 (65.4%) | 0.0044 | 0.055 | 0.38 | 0.0017 |
| Female | 143 (47.7%) | 26 (41.9%) | 90 (56.3%) | 27 (34.5%) | ||||
| Age, years | ||||||||
| Mean age (SD) | 66.1 (13.6) | 60.5 (15.7) | 68.1 (13.6) | 66.3 (10.2) | 0.00095 | 0.00056 | 0.1679 | 0.0215 |
| Median age | 67.0 | 65.5 | 70 | 65 | ||||
| Age at Tremor Onset, years | ||||||||
| Mean age at onset (SD) | 38.3 (21.0) | 34.3 (19.0) | 40.5 (22.0) | 36.9 (19.9) | 0.13 | 0.053 | 0.38 | 0.29 |
| Median age at onset | 41 | 33 | 45 | |||||
| Tremor duration, years | ||||||||
| Mean duration (SD) | 28.1 (18.8) | 26.0 (18.2) | 28.1 (19.1) | 29.6 (18.9) | 0.59 | 0.47 | 0.29 | 0.67 |
| Median duration | 23 | 22 | 22 | 25 | ||||
| Family History | ||||||||
| Tremor | 215 (71.7%) | 40 (64.5%) | 123 (76.9%) | 52 (66.7%) | 0.097 | 0.061 | 0.79 | 0.94 |
| PD | 58 (19.3%) | 16 (25.8%) | 23 (14.4%) | 19 (24.4%) | 0.066 | 0.045 | 0.84 | 0.058 |
| Dystonia | 8 (2.7%) | 2 (3.2%) | 6 (3.8%) | 0 (0.0%) | 0.2675 | 1 | 0.1943 | 0.1814 |
| Clinical Features by History | ||||||||
| Balance disturbance | 82 (27.3%) | 10 (16.1%) | 44 (27.5%) | 28 (35.9%) | 0.033 | 0.076 | 0.009 | 0.19 |
| Depression | 89 (29.7%) | 16 (25.8%) | 49 (30.6%) | 24 (30.8%) | 0.76 | 0.48 | 0.52 | 0.98 |
| Anxiety | 61 (20.3%) | 5 (8.1%) | 32 (20.0%) | 24 (30.8%) | 0.004 | 0.03 | 0.001 | 0.066 |
| RBD symptoms | 17 (5.7%) | 1 (1.6%) | 4 (2.5%) | 12 (15.4%) | 0.0003 | 1 | 0.005 | 0.0002 |
Adj. p = adjusted p (statistically significant cutoff of p < 0.017 by Bonferroni correction). SD = standard deviation, PD = Parkinson’s disease, RBD = rapid-eye movement behavior disorder, ET = essential tremor, ET plus = essential tremor plus, ET-PD = essential tremor-Parkinson’s disease.