Table 2.
Examination features.
| OVERALL | ET | ET PLUS | ET-PD | P (ALL) | ADJ. P (ET VS ET PLUS) | ADJ. P (ET VS ET-PD) | ADJ. P (ET PLUS VS ET-PD) | |
|---|---|---|---|---|---|---|---|---|
| Examination features | ||||||||
| Rest tremor | 130 (43.3%) | n/a | 64 (40.0%) | 66 (84.6%) | n/a | n/a | n/a | <0.0001 |
| Postural tremor | 294 (98.0%) | 62 (100.0%) | 157 (98.1%) | 75 (96.2%) | 0.35 | 0.56 | 0.25 | 0.40 |
| Kinetic tremor | 290 (96.7%) | 62 (100.0%) | 156 (97.5%) | 72 (92.3%) | 0.033 | 0.578 | 0.034 | 0.084 |
| Isometric tremor | 90 (30.0%) | 25 (40.3%) | 46 (28.8%) | 19 (24.4%) | 0.11 | 0.097 | 0.043 | 0.48 |
| Body areas involved | ||||||||
| Head | 141 (47.0%) | 20 (32.3%) | 95 (59.4%) | 26 (33.3%) | <0.0001 | 0.00029 | 0.89 | 0.00016 |
| Voice | 74 (24.7%) | 15 (24.2%) | 51 (31.9%) | 8 (10.3%) | 0.0014 | 0.26 | 0.027 | 0.00029 |
| Tongue | 41 (13.7%) | 7 (11.3%) | 27 (16.9%) | 7 (9.0%) | 0.21 | 0.30 | 0.65 | 0.10 |
| Upper limbs | 300 (100.0%) | 62 (100.0%) | 160 (100.0%) | 78 (100.0%) | n/a | n/a | n/a | n/a |
| Lower limbs | 70 (23.3%) | 13 (21.0%) | 43 (26.9%) | 22 (28.2%) | 0.91 | 0.97 | 0.71 | 0.68 |
| Trunk | 51 (17.0%) | 11 (17.7%) | 28 (17.5%) | 12 (15.4%) | 0.91 | 0.97 | 0.71 | 0.68 |
| Associated features | ||||||||
| Parkinsonism | 117 (39.0%) | n/a | 39 (24.4%) | 78 (100.0%) | n/a | n/a | n/a | <0.0001 |
| Dystonia | 75 (25.0%) | n/a | 68 (42.5%) | 7 (9.0%) | n/a | n/a | n/a | <0.0001 |
| Tandem gait abnormality | 69 (23.0%) | n/a | 62 (38.8%) | 7 (9.0%) | n/a | n/a | n/a | <0.0001 |
| Ataxia | 8 (2.7%) | n/a | 6 (3.8%) | 2 (2.6%) | n/a | n/a | n/a | 0.63 |
| Cognitive impairment | 45 (15.0%) | n/a | 26 (16.3%) | 19 (24.4%) | n/a | n/a | n/a | 0.134 |
| Neuropathy | 35 (11.7%) | 3 (4.8%) | 24 (15.0%) | 8 (10.3%) | 0.10 | 0.038 | 0.35 | 0.31 |
| TETRAS evaluations | ||||||||
| # patients | 88 (29.3%) | |||||||
| Mean performance subscore (SD) | 23.4 (6.75) | 19.7 (5.2) | 24.7 (6.5) | 21.8 (7.9) | 0.015 | 0.0047 | 0.39 | 0.15 |
| Mean ADL subscore (SD) | 21.2 (10.24) | 17.9 (8.4) | 24.0 (9.9) | 12.9 (8.4) | 0.00036 | 0.022 | 0.088 | 0.00037 |
| Average total score (SD) | 44.8 (15.47) | 37.8 (12.6) | 49.4 (15.0) | 33.6 (12.0) | 0.00022 | 0.00062 | 0.36 | 0.0005 |
Adj. p = adjusted p (statistically significant cutoff of p < 0.017 by Bonferroni correction). SD = standard deviation, ET = essential tremor, ET plus = essential tremor plus, ET-PD = essential tremor-Parkinson’s disease. TETRAS = The Essential Tremor Rating Assessment Scale, ADL = activities of daily living. Cognitive Impairment included MCI or dementia by neuropsychological testing, or MoCA score of ≤ 25. Some TETRAS scores had only ADL or performance subscores available, and were not included in the total score average.