Table 3.
Treatment history.
| OVERALL | ET | ET PLUS | ET-PD | P (ALL) | ADJ. P (ET VS ET PLUS) | ADJ. P (ET VS ET-PD) | ADJ. P (ET PLUS VS ET-PD) | |
|---|---|---|---|---|---|---|---|---|
| Medication History | ||||||||
| Average # of current oral medications (SD) | 1.92 (1.2) | 1.4 (1.0) | 1.8 (1.1) | 2.5 (1.3) | <0.0001 | 0.013 | <0.0001 | 0.00046 |
| Median # of current oral medications | 2 | 1 | 2 | 2 | ||||
| Average # of prior oral medications (SD) | 3.81 (1.9) | 3.1 (1.5) | 3.6 (1.8) | 4.7 (2.0) | <0.0001 | 0.058 | <0.0001 | <0.0001 |
| Median # of prior oral medications | 4 | 3 | 4 | 5 | ||||
| At least partially responsive | 213 (71.0%) | 43 (69.4%) | 105 (65.5%) | 65 (83.3%) | 0.018 | 0.60 | 0.050 | 0.005 |
| Improved tremor with alcohol | 79 (26.3%) | 16 (25.8%) | 44 (27.5%) | 19 (24.4%) | 0.87 | 0.80 | 0.84 | 0.61 |
| BoNT Injections | ||||||||
| Received BoNT injections | 123 (41.0%) | 26 (41.9%) | 81 (50.6%) | 16 (20.5%) | <0.0001 | 0.25 | 0.006 | <0.0001 |
| BoNT effective | 91/123 (74.0%) | 21 (80.8%) | 59 (72.8%) | 11 (68.8%) | 0.64 | 0.42 | 0.46 | 0.76 |
| DBS | ||||||||
| Underwent DBS placement | 38 (12.7%) | 11 (17.7%) | 17 (10.6%) | 10 (12.8%) | 0.36 | 0.15 | 0.42 | 0.62 |
| DBS effective | 35/38 (92.1%) | 11 (100.0%) | 15 (88.2%) | 9 (90.0%) | 0.601 | 0.51 | 0.48 | 1 |
Adj. p = adjusted p (statistically significant cutoff of p < 0.017 by Bonferroni correction). ET = essential tremor, ET plus = essential tremor plus, ET-PD = essential tremor-Parkinson’s disease, SD = standard deviation, BoNT = botulinum toxin, DBS = deep brain stimulation.