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. 2021 Apr 1;35(7-8):489–494. doi: 10.1101/gad.345397.120

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© 2021 Shao et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Peak-2^KO/y mice show age-related behavioral deficits and abnormal RTT-like gene expression. (A) Peak-2^KO/y mice traveled further and displayed more activity counts in the open field assay than their wild-type littermates in open field assay at 10 wk of age (n = 12). (B) Peak-2^KO/y mice show anxiety-like phenotypes as measured by decreased entries, less time spent, and decreased distance in the open arms in the elevated plus maze at 24 wk of age (n = 12). (C) Peak-2^KO/y mice show social deficits as measured by decreased time investigating a novel mouse in the three-chamber sociability assay at 24 wk of age (n = 12). (D) Peak-2^KO/y mice show social dominance deficits as measured by decreased winning percentage in the tube test at 40 wk of age (n = 12). Data are presented as mean ± SEM. All data were analyzed by two-tailed t-test. (*) P < 0.05, (**) P < 0.01, (***) P < 0.001, (ns) not significant.