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. 2021 Apr 1;35(7-8):489–494. doi: 10.1101/gad.345397.120

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© 2021 Shao et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Peak-6^KO/y mice show abnormal MDS-like gene expression and behavioral deficits. (A) Peak-6^KO/y mice show hypoactivity, with fewer activity counts in open field assay at 9 wk of age (n = 13–15). (B) Peak-6^KO/y mice show anxiety-like phenotypes as evidenced by decreased entries and time spent at the center in open field assay at 9 wk of age (n = 13–15). (C) Peak-6^KO/y mice show anxiety-like phenotypes as measured by reduced entries to the open arms in the elevated plus maze at 10 wk of age (n = 13–15). (D) Peak-6^KO/y mice show learning and memory deficits using a fear conditioning test at 36 wk of age (n = 13–15). Data are presented as mean ± SEM. All data were analyzed by two-tailed t-test. (*) P < 0.05, (**) P < 0.01.