Skip to main content
. 2021 Apr 1;35(7-8):528–541. doi: 10.1101/gad.340505.120

Figure 6.

Figure 6.

High survivin expression is detected in human ESCC and metastases and in other GI cancers. (A) Analysis of TCGA-ESCA database (n = 143) revealed significant increase of survivin expression in primary esophageal carcinoma tissue compared with normal tissue. P < 0.0001. (B) IHC staining of survivin and p53 in tissue microarrays (TMAs) of paired ESCC primary tumor and normal tissue. Scale bar, 100 µm. (C) Increased level of survivin is detected in ESCC primary tumor compared with paired normal tissue. n = 17 pairs, P = 0.0014, Wilcoxon matched-pairs signed rank test. Scoring standards: (0.5) <10% positive cells positive nuclei, (1) 10%–25% positive cells positive nuclei, (2) 25%–50% positive cells positive nuclei, (3) >50% positive cells positive nuclei. Error bars represent SEM. Increased expression of survivin is correlated with p53 nuclear accumulation in ESCC. n = 59, P = 0.027, Spearman's rank correlation test. (D) Analysis of TCGA pancreatic ductal adenocarcinoma (PDAC) data set (TCGA-PAAD, n = 185) showed that survivin expression is significantly elevated in PDAC tumors with metastasis. P = 0.01. (E) Analysis of RNA-seq (GSE68468, n = 27) in colorectal cancers reveals increased survivin levels in lung metastases compared with adjacent normal tissues. P = 0.0002.