Table 2. Comparison of MADRS scores and pBDNF concentrations between responders and nonresponders and between remitters and nonremitters in patients with unipolar and bipolar depression using linear mixed model analysis.
Outcomes | Variables | Group-by-time interaction | Time main effect | Group main effect | |||
---|---|---|---|---|---|---|---|
F | p | F | p | F | p | ||
Responders vs. nonresponders | MADRS scores | 59.79 | <0.001 | 223.39 | <0.001 | 59.32 | <0.001 |
pBDNF concentrations (ng/ml) | 0.04 | 0.837 | 8.55 | <0.001 | 3.90 | 0.024 | |
Remitters vs. nonremitters | MADRS scores | 74.95 | <0.001 | 263.13 | <0.001 | 29.52 | <0.001 |
pBDNF concentrations (ng/ml) | 0.02 | 0.888 | 6.40 | 0.003 | 2.61 | 0.079 |
Notes.
Bolded values are p < 0.05.
- pBDNF
- plasma brain derived neurotrophic factor
- MADRS
- Montgomery-Asberg Depression Rating Scale