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Comparison of unimodal and joint clustering by Specter. CBMCs (A,B) and PBMCs (C,D) with coordinates of protein expression (ADT) along the CD4 and CD8 axes. Cells are clustered by Specter into CD4 T cells (blue) and CD8 T cells (red) either based on mRNA expression alone (A,C) or jointly from mRNA and surface protein expression (B,D). The mixing of CD4 T cells and CD8 T cells in the mRNA-based clustering is corrected through the co-association of both modalities by Specter.
