Table 1. Baseline Patient Characteristics.
| Characteristic | Patients, No. (%) | ||
|---|---|---|---|
| Total (N = 2007) | sLAVO | ||
| Yes (n = 158) | No (n = 1849) | ||
| Age, mean (SD), y | 71.1 (14.9) | 72.4 (13.3) | 70.9 (14.9) |
| Male sex | 1021 (50.9) | 92 (58.2) | 929 (50.2) |
| Stroke logistics | |||
| Primary stroke center | 781 (38.9) | 32 (20.3)a | 749 (40.5) |
| Comprehensive stroke center | 1226 (61.1) | 126 (79.7) | 1100 (59.5) |
| Medical history | |||
| Ischemic stroke or transient ischemic attack | 671 (33.4) | 33 (20.9) | 638 (34.5) |
| Intracerebral hemorrhage | 83 (4.1) | 2 (1.3) | 81 (4.4) |
| Atrial fibrillation | 273 (13.6) | 30 (19.0) | 243 (13.2) |
| Diabetes | 421 (21.0) | 37 (23.4) | 384 (20.8) |
| Hyperlipidemia | 817 (40.7) | 48 (30.4) | 769 (41.6) |
| Hypertension | 1179 (58.7) | 88 (55.7) | 1091 (59.0) |
| Myocardial infarction | 223 (11.1) | 20 (12.7) | 203 (11.0) |
| Medication use | |||
| Oral anticoagulation | 337 (16.8) | 24 (15.2) | 313 (16.9) |
| Antiplatelets | 690 (34.4) | 50 (31.6) | 640 (34.6) |
| Hospital admission | |||
| NIHSS score, median (IQR)b | 4 (2-8) | 11 (5-17) | 3 (2-6) |
| ODT, median (IQR), minb | 140 (59-441) | 115 (45-340) | 142 (62-446) |
| Wake-up strokeb | 235 (23.7) | 46 (29.7) | 189 (22.6) |
| Blood pressure, median (IQR), mm Hg | |||
| Systolic | 160 (140-182) | 157 (139-182) | 160 (140-182) |
| Diastolic | 87 (77-100) | 87 (75-99) | 87 (77-100) |
| Glucose level, median (IQR), mg/dL | 6.6 (5.7-8.1) | 6.8 (5.9-8.6) | 6.6 (5.7-8.1) |
| Atrial fibrillation de novo | 79 (3.9) | 13 (8.2) | 66 (3.6) |
| Reperfusion therapy | |||
| IVTc | 314 (15.6) | 61 (38.6) | 253 (13.7) |
| EVTd | 100 (5.0) | 100 (63.3) | NA |
| IVT + EVT | 43 (2.1) | 43 (27.2) | NA |
| In-hospital performance metrics, median (IQR), min | |||
| DNT | 25 (19-34) | 24 (18-33) | 25 (19-34) |
| DGT | 72 (54-105) | 72 (54-105) | NA |
| Site of occlusion | |||
| ICA(-T) | 28 (1.4) | 24 (15.2) | NA |
| MCA M1 | 77 (3.8) | 75 (47.5) | NA |
| MCA M2 | 75 (3.7) | 73 (46.2) | NA |
| ACA 1/2 | 5 (0.2) | 5 (3.2) | NA |
| Othere | 29 (1.4) | 5 (3.2) | 24 (1.3) |
| Final diagnosis after 90 d | |||
| Ischemic stroke | 842 (41.9) | 155 (98.1) | 687 (37.2) |
| Intracerebral hemorrhage | 148 (7.4) | 0 | 148 (8.0) |
| Transient ischemic attack | 264 (13.2) | 3 (1.9) | 261 (14.1) |
| Stroke mimic | 753 (37.5) | 0 | 753 (40.7) |
| mRS after 90 d, median (IQR)b,f | 2 (1-4) | 3 (2-6) | 2 (1-4) |
Abbreviations: ACA, anterior cerebral artery; DGT, first-door-to-groin-puncture time for EVT; DNT, door-to-needle time for IVT; EVT, endovascular thrombectomy; ICA(-T), intracranial carotid artery or tandem ICA; IQR, interquartile range; IVT, intravenous thrombolysis; MCA M1 or M2, middle cerebral artery segment M1 or M2; mRS, modified Rankin scale; NA, not applicable; NIHSS, National Institutes of Health Stroke Scale; ODT, onset to hospital door; sLAVO, symptomatic large anterior vessel occlusion.
SI conversion factor: To convert glucose level to mmol/L, multiply by 0.0555.
Of 32 patients with sLAVO, 27 (84.4%) were transferred to a comprehensive stroke center for EVT or observation.
Only provided for patients with stroke (ie, ischemic stroke and intracerebral hemorrhage).
Missing data in 3.5%.
No missing data.
Large posterior vessel occlusion locations: basilar artery, vertebral artery, and posterior cerebral artery, segments P1 or P2.
Missing data in 36.2%.