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. 2021 Feb 26;11:590154. doi: 10.3389/fphar.2020.590154

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Copyright © 2021 Dash, Mohapatra, Ghosh and Nayak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spike interactions with the ACE2 receptor of the host. (A) Represents the pre-fusion structure of S glycoprotein of SARS-CoV-2 (PDB ID-6VSB). It has a predominant state of trimers with receptor accessible conformation of one of the three RBD due to the upward rotation. The structure represents three chains (A represented in green color, B represented in violet color and C represented in red color); (B) Represents the crystal structure of SARS-CoV-2 spike RBD bound with ACE2 receptor of humans (PDB ID-6MOJ).