TABLE 1.
Cross‐sectional analyses comparing female and male patients with Huntington's disease (HD) at visit 4. Only CAG ≥36 and manifest HD subjects from enroll‐HD which meet the criteria for inclusion into the dataset as of December 14, 2018 (PDS4) and who completed at least four study visits were included in these analyses (N = 2145)
| Sex | |||
|---|---|---|---|
| Female (N = 1097) | Male (N = 1048) | P value | |
| Age in years at visit 4 [mean ± SD (median)] | 54.4 ± 12.1 (55) | 55.6 ± 12.2 (56) | 0.028 a b |
| Days relative to baseline date of Enroll‐HD at visit 4 [mean ± SD (median)] | 1098 ± 128 (1099) | 1098 ± 129 (1099) | 0.951 a |
| Age of clinical HD diagnosis [mean ± SD (median)] | 47.5 ± 11.8 (48) | 48.9 ± 12.0 (50) | 0.017 a b |
| CAG repeats [mean ± SD (median)] | 43.9 ± 3.6 (43) | 43.8 ± 3.8 (43) | 0.075 a |
| Medical history of: | |||
| Alcohol abuse (%) | 32.0 | 42.4 | <0.001 c |
| Smoking (%) | 23.4 | 18.3 | 0.013 c |
| Drugs abuse (%) | 2.2 | 3.2 | 0.320 c |
| Depression (%) | 80.9 | 71.4 | <0.001 c |
| Irritability (%) | 73.5 | 74.4 | 0.880 c |
| Violent/aggressive behavior (%) | 41.9 | 45.6 | 0.228 c |
| Perseverative/obsessive behavior (%) | 59.6 | 61.4 | 0.711 c |
| Apathy (%) | 71.5 | 68.0 | 0.131 c |
| Psychosis (%) | 14.0 | 12.2 | 0.281 c |
| Significant cognitive impairment (%) | 64.9 | 61.5 | 0.225 c |
| Previous suicidal ideation (%) | 34.4 | 31.5 | 0.171 c |
Medical history data were collected at the Enroll‐HD baseline visit and verified again at every annual visit.
a
Mann‐Whitney test.
b
The differences are not significant when controlling for the CAP score.
c
Pearson chi‐square test. Significant values are highlighted in bold.
SD, standard deviation.