Table 2.
Macroscopic and microscopic features
| RMC | CDC | FH-deficient RCC | p-value | |
|---|---|---|---|---|
| Macroscopic features | ||||
| Location; medulla cortex & medulla | 56% (18/32) 44% (14/32) |
41% (14/34) 44% (15/34) |
13% (3/24) 67% (16/24) |
NA |
| Infiltrating border | 69% (22/32) | 78% (25/32) | 50% (11/22) | 0.110 |
| Renal vein invasion | 41% (13/32) | 44% (14/32) | 30% (7/23) | 0.669 |
| Microscopic features | ||||
| #1 (infiltrating gland) | 55% (18/33) | 74% (28/38) | 48% (14/29) | 0.0775 |
| #2 (MIP) | 0% (0/33) | 26% (10/38) | 10% (3/29) | < 0.0167 |
| #3 (tubular, papillary) | 36% (12/33) | 84% (32/38) | 86% (25/29) | < 0.0167 |
| #4 (solid sheet, cord, nest) | 97% (32/33) | 95% (36/38) | 79% (23/29) | 0.436 |
| #5 (intracystic papillary) | 15% (5/33) | 16% (6/38) | 55% (16/29) | < 0.0167 |
| #6 (sieve-like/cribriform) | 88% (29/33) | 39% (15/38) | 62% (18/29) | < 0.0167 |
| #7 (tubulocystic) | 0% (0/33) | 0% (0/38) | 66% (19/29) | < 0.0167 |
| #8 (reticular/YST-like) | 85% (28/33) | 8% (3/38) | 3% (1/29) | < 0.0167 |
| HLRCC-like nucleoli (1+; 2+) |
39% (13/33) (30%; 9%) |
40% (15/38) (29%; 11%) |
100% (29/29) (21%; 79%) |
< 0.0167 |
| Coagulative necrosis | 64% (21/33) | 68% (26/38) | 17% (5/29) | < 0.0167 |
| Dysplastic in situ change | 6% (2/33) | 42% (16/38) | 11% (3/28) | < 0.0167 |
| Stromal myxoid change | 94% (31/33) | 26% (10/38) | 39% (11/28) | < 0.0167 |
| Sarcomatoid change | 15% (5/33) | 29% (11/38) | 28% (8/19) | 0.388 |
| ISUP/WHO grade 3, 4 | 58% (19/33), 42% (14/33) |
63% (24/38), 37% (14/38) |
72% (21/29), 28% (8/29) |
0.475 |
MIP; multinodular infiltrating papillary, YST: yolk sac tumor