Representative image of near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS) imaging pre- and post-stenting of high lipid burden and low lipid burden lesions; A, C. NIRS maps pre- and post-stent implantation. Black lines indicate stent edges. Black dashed lines limit 4 mm proximal and distal segments adjacent to the stent. White dashed lines indicate the NIRS-IVUS cross-section image. B, D. NIRS-IVUS cross-sectional image of minimal lumen area (MLA), external elastic lamina (EEM) and stent contours. High lipid burden lesion: A. Pre-stenting maxLCBI4 mm = 548; C. Post-stenting maxLCBI4 mm = 202; B. Pre-stenting: MLA = 3.8 mm2, plaque burden = 71%, plaque area = 9.2 mm2, EEM area = 12.9 mm2, remodeling index = 1.34; D. Post-stenting: MLA = 6.4 mm2, plaque burden = 48.8%, plaque area = 6.1 mm2, EEM area = 12.4 mm2, stent area = 5.0 mm2, remodeling index = 1.22; delta mean plaque volume = 22.9 mm3. Low lipid burden lesion: A. Pre-stenting maxLCBI4 mm = 137; C. Post-stenting maxLCBI4 mm = 30; B. Pre-stenting: MLA = 3.5 mm2, plaque burden = 61%, plaque area = 6.4 mm2, EEM area = 10.6 mm2, remodeling index = 0.72; D. Post-stenting: MLA = 5.8 mm2, plaque burden = 53%, plaque area = 6.4 mm2, EEM area = 12.0 mm2, stent area = 6.6 mm2, remodeling index = 1.29; delta mean plaque volume = 8.2 mm3.