MiR-1/133 mimics improved pathological changes and reduced cardiomyocyte apoptosis in viral myocarditis (VMC) mouse hearts. A. H&E staining of myocardium in different group mice (magnification: 10 × 40); a. Control group (Ctr), b. VMC group, c. VMC + negative control (NC) group, d. VMC + miR-1/133 mimics group; B. TUNEL staining showed cardiomyocytes apoptosis of different group mice (10 × 40). Cells with brown nuclei were TUNEL positive, and cells with blue nuclei represented normal cells; a. Control group, b. VMC group, c. VMC+miR-1/133 NC group, d. VMC + miR-1/133 mimics group; C. Quantified cell apoptosis data. Data are expressed as mean ± standard error (SE). N = 10, *p < 0.01 vs. control, #p < 0.01 vs. VMC and VMC + NC group; for other abbreviations — see text.