Table 2.
Association between inner cell mass or trophectoderm grade and pregnancy outcome after euploid frozen embryo transfer.
| Outcome | Crude OR (95% CI) | P value | Adjusted OR (95% CI)a | P value |
|---|---|---|---|---|
| ICM grade Bb | ||||
| Live birth | 0.75 (0.53–1.06) | .10 | 0.80 (0.56–1.14) | .21 |
| Clinical miscarriage | 1.12 (0.42–3.02) | .82 | 1.53 (0.85–2.77) | .16 |
| Biochemical pregnancy loss | 0.87 (0.48–1.57) | .64 | 0.87 (0.47–1.62) | .66 |
| TE grade Bb | ||||
| Live birth | 0.86 (0.62–1.21) | .38 | 0.90 (0.63–1.27) | .53 |
| Clinical miscarriage | 1.33 (0.78–2.27) | .30 | 1.37 (0.79–2.39) | .27 |
| Biochemical pregnancy loss | 1.04 (0.57–1.90) | .90 | 1.08 (0.58–2.00) | .82 |
| ICM grade Cb | ||||
| Live birth | 0.45 (0.22–0.90) | .02 | 0.50 (0.24–1.02) | .057 |
| Clinical miscarriage | 1.68 (0.58–4.82) | .34 | 1.67 (0.56–5.00) | .36 |
| Biochemical pregnancy loss | 1.58 (0.55–4.52) | .40 | 1.58 (0.53–4.75) | .42 |
| TE grade Cb | ||||
| Live birth | 0.47 (0.28–0.79) | .004 | 0.49 (0.28–0.86) | .01 |
| Clinical miscarriage | 1.86 (0.88–3.94) | .11 | 2.00 (0.89–4.47) | .09 |
| Biochemical pregnancy loss | 1.74 (0.77–3.93) | .18 | 1.85 (0.77–4.44) | .17 |
Note: AMH = antimüllerian hormone; BMI = body mass index; CI = confidence interval; ICM = inner cell mass; OR = odds ratio; TE = trophectoderm.
a
Adjusted for age (continuous), overweight (categorical, BMI ≥25 kg/m2 or BMI <25 kg/m2), AMH (categorical, <1 ng/mL or ≥1 ng/mL), and day of blastocyst biopsy (5, 6, or 7).
b
Logistic regression model, ICM or TE grade A used as reference.