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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Am J Obstet Gynecol. 2020 Feb 27;223(3):404.e1–404.e20. doi: 10.1016/j.ajog.2020.02.027

Table 2b.

Risk of Severe Maternal Morbidity by Fertility Group*

AOR (95% CI)
Infertile
Treatment vs Fertile Diagnosis vs Fertile Testing vs Fertile All infertile vs fertile
Severe maternal morbidity indicator
Any severe maternal morbidity indicator 1.24 (1.12 – 1.37) 1.22 (1.13 – 1.33) 1.09 (0.81 – 1.45) 1.22 (1.14 – 1.31)
Acute myocardial infarction 1.68 (0.52 – 5.46) 0.90 (0.22 – 3.69) ** 1.33 (0.52 – 3.36)
Acute renal failure 1.03 (0.53 – 2.02) 0.86 (0.47 – 1.57) ** 0.84 (0.51 – 1.38)
Acute respiratory distress 1.57 (1.03 – 2.38) 1.14 (0.76 – 1.71) ** 1.26 (0.93 – 1.70)
Amniotic fluid embolism 1.61 (0.50 – 5.18) 1.10 (0.35 – 3.49) ** 1.31 (0.57 – 3.02)
Aneurysm ** ** ** **
Cardiac arrest or ventricular fibrillation 1.22 (0.29 – 5.04) 2.68 (1.16 – 6.20) ** 1.94 (0.88 – 4.31)
Disseminated intravascular coagulation 1.67 (1.33 – 2.09) 1.34 (1.08 – 1.66) 1.57 (0.81 – 3.04) 1.48 (1.26 – 1.73)
Eclampsia 1.49 (1.02 – 2.17) 1.30 (0.95 – 1.79) 0.41 (0.06 – 2.91) 1.37 (1.05 – 1.79)
Heart failure during procedure or surgery 1.27 (0.85 – 1.91) 1.75 (1.3 – 2.36) 0.89 (0.22 – 3.57) 1.54 (1.21 – 1.97)
Internal injuries of the thorax, abdomen, or pelvis 1.61 (0.92 – 2.84) 1.52 (0.95 – 2.45) 0.99 (0.14 – 7.08) 1.77 (1.20 – 2.61)
Intracranial injuries 1.27 (0.31 – 5.28) 2.64 (1.14 – 6.10) ** 2.05 (0.97 – 4.32)
Puerperal cardiovascular disorders 1.05 (0.77 – 1.43) 1.41 (1.13 – 1.75) 1.65 (0.81 – 3.35) 0.94 (0.66 – 1.33)
Pulmonary edema 1.85 (1.09 – 3.14) 2.05 (1.36 – 3.08) ** 2.18 (1.54 – 3.10)
Severe anesthesia complications 0.33 (0.08 – 1.35) 0.85 (0.42 – 1.71) ** 1.13 (0.49 – 2.60)
Sepsis 1.04 (0.58 – 1.85) 0.70 (0.40 – 1.21) 1.37 (0.34 – 5.51) 0.90 (0.59 – 1.36)
Shock 1.76 (1.02 – 3.05) 1.06 (0.58 – 1.93) ** 1.14 (0.72 – 1.80)
Sickle cell anemia with crisis ** ** ** **
Thrombotic embolism 1.35 (0.86 – 2.13) 1.77 (1.27 – 2.49) 1.21 (0.30 – 4.88) 1.58 (1.14 – 2.17)
Blood transfusion 1.69 (1.39 – 2.07) 1.30 (1.08 – 1.56) 1.44 (0.79 – 2.62) 1.50 (1.30 – 1.72)
Cardiology monitoring 1.01 (0.87 – 1.18) 1.14 (1.02 – 1.27) 0.83 (0.53 – 1.29) 1.09 (0.997 – 1.20)
Conversion of cardiac rhythm 0.72 (0.10 – 5.29) 0.95 (0.23 – 3.88) ** 0.83 (0.26 – 2.68)
Hysterectomy 1.61 (1.03 – 2.52) 1.10 (0.69 – 1.77) 1.53 (0.38 – 6.16) 1.35 (0.97 – 1.88)
Operations on the heart and pericardium 1.44 (0.86 – 2.39) 1.09 (0.67 – 1.77) 2.23 (0.72 – 6.96) 1.12 (0.77 – 1.64)
Temporary tracheostomy ** ** ** **
Ventilation 0.95 (0.61 – 1.47) 1.08 (0.78 – 1.51) ** 0.91 (0.69 – 1.20)
Intubation 0.92 (0.29 – 2.92) 0.98 (0.40 – 2.39) ** 0.84 (0.39 – 1.80)
*

GEE (generalized estimating equation) model was used to estimate the odds ratios of the diseases between infertile and control groups, adjusted for maternal age, year of delivery, nulliparity, delivery mode, preterm birth, obesity, smoking, hypertension, diabetes, number of prenatal visits, race and ethnicity, and education, accounting for women who had more than one delivery of a singleton during the database enrollment period.

**

Calculation of AOR and 95% CI not possible due to small numbers