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Design of dual GSK-3β/tau aggregation inhibitors. The 5-arylidene-2,4-thiazolidinedione has been designed taking into consideration that a five-member heterocycle is a moiety present in both GSK-3β and tau aggregation inhibitors and that a planar substituent in position 5 may increase both the selectivity toward GSK-3β and the interactions with the tau fibrils.
