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. 2021 Apr 1;16(4):e0247671. doi: 10.1371/journal.pone.0247671

Fig 5. Correlated pairs of genes share common regulators in synthetic GRN.

Fig 5

A) Typical average topological distance (a measure of regulatory proximity in the GRN) between pairs of highly correlated genes (/R/ > 0.8) compared with the average distance between random pairs of background genes in the synthetic regulatory network. In both cases, the associated p value in a T test was below 10–16. B) Bar chart showing the average proportion (±S.E.M) of pairs of genes sharing a common regulator among either highly correlated pairs (/R/ >0.8) or lowly correlated pairs (/R/ < 0.2) found in 1000 independent simulations.