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. 2021 Mar 22;17(3):e1009446. doi: 10.1371/journal.pgen.1009446

Fig 7. Signaling pathways regulating NCCs proliferation and differentiation are downregulated in BAF155/170 mutants.

Fig 7

(A) GSEA analysis showed that genes controlling cell cycle progression were negatively enriched while genes controlling apoptosis were positively enriched. (B) MA plots showing down-regulation of genes associated with critical pathways essential for NCCs proliferation, migration, and differentiation. (C-D) Relative mRNA levels of Notch (C) and Hippo (D) pathway genes in control and BAF155/170-deficient (Wnt1Cre/+;BAF155fl/fl;BAF170fl/fl) sorted NCCs. n = 3–4 each genotype. (E) Relative mRNA levels of PlexinA2 in control and BAF155/170-deficient (Wnt1Cre/+;BAF155fl/fl;BAF170fl/fl) sorted NCCs. Values are reported as means ± SEM (*P < 0.05, **P < 0.01, ***P < 0.001; NS, not significant).