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. 2021 Mar 22;17(3):e1009446. doi: 10.1371/journal.pgen.1009446

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© 2021 Bi-Lin et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 9 — (A) Venn diagram on transcription factors which show significant enrichments in the BAF155/170-deficient (Wnt1^Cre/+;BAF155^fl/fl;BAF170^fl/fl) NCCs compared to the controls. RNAseq data were analyzed via Enrichr, Pscan, and iCisTarget. (B) Fisher’s test showing enrichment of differentially expressed neural crest genes in scRNAseq clusters identified by Soldato et al., 2019. (C) GSEA analysis showed that custom pathways (with cluster genes identified by Soldato et al., 2019, highlighted with blue color) are retrieved as top GSEA hits (top 20 pathways are presented). Pathways that are significant in the Fisher test occupy a higher rank in the GSEA output. (D) GSEA was performed to analyze the custom pathways affected by BAF155/170 deletion in NCCs.