Heatmap of all biological replicates from different E. multilocularis samples based on normalized miRNA read counts. MiRNA expression level is displayed using a color key where red represents miRNAs with high expression and blue indicates miRNAs with low expression. Hierarchical clustering at a sample level is shown. Three miRNA clusters are also indicated with breaks. MCvivo: metacestodes extracted from experimentally infected jirds, MCvitro: metacestodes cultured in vitro in aerobic conditions, MCana: metacestodes cultured in vitro in axenic and anaerobic conditions, naPS: non-activated protoscoleces, aPS: activated protoscoleces, PC1: primary cell cultured in vitro for 48 hs, PC2: primary cells cultured in vitro for 7 days and PC3: primary cells cultured in vitro for 21 days.