Table 1. Demographic and clinical characteristics of 73 pediatric patients with MRSA bacteremia.
| Characteristics | Number of cases (%) or median values (interquartile range) |
|---|---|
| Median age, months | 12.4 (5.3–36.1) |
| Sex (number; % of male) | 43 (58.9%) |
| Hospital stay before the onset of the MRSA bacteremia, days | 13.0 (4.0–33.0) |
| Presence of bacterial co-infectiona | 5 (6.8%) |
| Presence of invasive device b | 58 (79.5%) |
| Presence of fever ≥ 38°C at the onset of bacteremia | 55 (75.3%) |
| Presence of underlying diseases | 71 (97.3%) |
| Congenital heart disease | 21 (28.8%) |
| Malignancy | 12 (16.4%) |
| Chronic lung disease | 4 (5.5%) |
| Neurologic diseases | 5 (6.8%) |
| Others c | 15 (20.5%) |
| Primary focus of MRSA bacteremia | |
| None | 31 (42.5%) |
| Central vascular catheter | 25 (34.2%) |
| Lung | 8 (11.0%) |
| Others d | 9 (12.3%) |
| Initial laboratory findings | |
| Serum WBC (/uL) | 13,500 (8,600–19,300) |
| CRP (mg/dL) | 3.1 (0.8–6.7) |
| Serum Creatinine (mg/dL) | 0.3 (0.2–0.4) |
| Parameters related to vancomycin regimen | |
| Initial vancomycin dose (mg/kg/day) | 40.0 (40.0–55.0) |
| Initial vancomycin C trough concentration (mg/L) | 6.4 (4.3–11.6) |
| Initial AUC/MIC | 336.4 (271.4–422.6) |
| Simultaneous use of other antibiotics (%) | 63 (86.3%) |
| Recurrent bacteremia e | 14 (19.4%) |
| Persistent bacteremia at 48–72 hours | 29 (39.7%) |
| Acute kidney injury | 3 (4.1%) |
| All-cause 30 day-mortality e | 7 (9.7%) |
a Bacterial co-infection occurred in a total of 5 patients, all of which were bacteremia due to Enterococcus faecalis (n = 2), Klebsiella aerogenes (n = 1), K. pneumoniae (n = 1), and Pseudomonas aeruginosa (n = 1).
b Invasive devices included central vascular catheter (n = 46), gastrostomy (n = 5), tracheostomy (n = 5), ventriculo-peritoneal shunt (n = 2).
c Others included congenital diaphragmatic hernia (n = 2), congenital megacolon (n = 2), short bowel syndrome (n = 3), acute respiratory distress syndrome (n = 3), omphalocele (n = 1), trachea-esophagus fistula (n = 1), jejunal atresia (n = 1), pseudohypoaldosteronism (n = 1), VACTERL (vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, and limb abnormalities association) (n = 1).
d Others included skin and soft tissue infection (n = 7), ventriculo-peritoneal shunt infection (n = 2).
e One out of 73 patients with MRSA bacteremia was transferred to another hospital during treatment, allowing analysis of mortality and recurrence rates in a total of 72 patients excluding it.