Table 4. Risk factors for persistence of MRSA bacteremia at 48–72 hours and 30-day all-cause mortality.
| Variable | Persistent bacteremia at 48–72 hours | 30-day all-cause mortality | ||
|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | |||
| Unadjusted | Adjusted | Unadjusted | Adjusted | |
| Age | 1.00 (0.99–1.01) | 1.00 (0.99–1.01) | 1.01 (0.99–1.02) | 1.00 (0.99–1.02) |
| Bacterial co-infection a | 1.15 (0.18–7.34) | 1.37 (0.20–9.49) | 0.00 | 0.00 |
| Presence of invasive device b | 1.81 (0.51–6.37) | 1.60 (0.42–6.13) | 2.57 (0.30–22.07) | 2.42 (0.27–21.76) |
| Presence of primary focus | 2.38 (0.87–6.51) | 1.92 (0.66–5.56) | 1.87 (0.44–7.89) | 1.85 (0.41–8.28) |
| Initial Ctrough < 10 μg /mL | 3.37 (1.00–11.41) | 3.14 (0.86–11.41) | 1.73 (0.34–8.91) | 1.42 (0.26–7.78) |
| Initial AUC/MIC < 300 | 3.43 (1.24–9.45) | 3.05 (1.07–8.68) | 0.80 (0.19–3.40) | 0.60 (0.13–2.73) |
a Bacterial co-infection occurred in a total of 5 patients, all of which were bacteremia due to E. faecalis (n = 2), K. aerogenes (n = 1), K. pneumoniae (n = 1), and P. aeruginosa (n = 1).
b Invasive devices included central vascular catheter (n = 46), gastrostomy (n = 5), tracheostomy (n = 5), ventriculo-peritoneal shunt (n = 2).