Figure 7. Summary of hypothesized alterations in D1 receptor function and endocannabinoid signaling in D1 SPNs of CIE-exposed mice.

In Air controls (left), D1 receptor activity regulates endocannabinoid production and/or release. In CIE mice (right), the loss of D1 receptor function leads to unregulated endocannabinoid signaling and the long-term reduction in glutamate release from OFC inputs.