Table 2.
DAD score, protein levels [pg mg−1], and gene expression of pulmonary markers [relative mRNA expression, fold-change compared with the house-keeping-gen hypoxanthin-phosphoribosyl-transferase-1]. Values are given as median and quartiles. Statistical significance was accepted at P>0.05. Dad score diffuse alveolar damage score; IL-6, interleukin 6; ELISA, enzyme-linked immunosorbent assay, IL-8, interleukin 8; mRNA, messenger ribonucleic acid; VEGF, vascular endothelial growth factor; ICAM-1, intercellular adhesion molecule 1. VV, variable ventilation, NV nonvariable ventilation; mRNA, messenger RNA.
| Group | DAD score | IL-6 ELISA | IL-8 ELISA | IL-6 mRNA | IL-8 mRNA | VEGF mRNA | ICAM-1 mRNA | Type III procollagen mRNA |
|---|---|---|---|---|---|---|---|---|
| VV | 15.1 (12.5–17.1) | 44.2 (38.6–49.3) | 109.3 (99.4–136.3) | 0.6 (0.5–1.1) | 0.8 (0.8–1.2) | 0.9 (0.9–1.2) | 1.0 (0.9–1.2) | 1.2 (1.0–1.3) |
| NV | 10.4 (8.0–23.3) | 47.0 (38.5–60.3) | 165.6 (111.4–272.2) | 0.7 (0.4–1.7) | 1.7 (1.1–4.0) | 1.1 (0.9–1.2) | 1.0 (0.9–1.4) | 1.1 (0.9–1.1) |
| P-value | 0.565 | 0.482 | 0.085 | 0.655 | 0.110 | 0.749 | 0.565 | 0.142 |