Fig. 2.

Heatmaps of genes in IMIX analysis for bladder cancer molecular subtypes in TCGA. (a) Methylation, gene expression and copy number variation (CNV) patterns of top significant genes associated with the three data types (M+,GE+,CNV+) identified by IMIX in molecular subtypes of TCGA muscle-invasive bladder cancer patients, with adaptive FDR control at $\alpha =0.01$, estimated marginal FDR (${\widehat{\text{mFDR}}}_8$) = 0.0098. (b) Expression patterns of luminal and basal markers of TCGA bladder cancer cohort