Table 2.
Univariate and multivariate Cox analysis of the determinants of overall survival (OS) of patients with gastric signet ring cell carcinoma (GSRC).
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age at diagnose (years) | ||||
| 18-44 | 1 | |||
| 45-64 | 1.118 (0.937-1.334) | 0.215 | ||
| Race | ||||
| Black | 1 | 1 | ||
| Other | 0.672 (0.517-0.873) | 0.003 | 0.658 (0.501-0.864) | 0.003 |
| White | 0.948 (0.765-1.174) | 0.624 | 0.870 (0.694-1.090) | 0.226 |
| Sex | ||||
| Female | 1 | |||
| Male | 0.974 (0.840-1.129) | 0.722 | ||
| Marital status | ||||
| Married | 1 | 1 | ||
| Unmarried | 1.210 (1.036-1.412) | 0.016 | 1.108 (0.943-1.301) | 0.214 |
| Primary site | ||||
| Proximal third (cardia and fundus) | 1 | 1 | ||
| Mid third (body and lesser curvature) | 0.741 (0.588-0.934) | 0.011 | 0.815 (0.642-1.035) | 0.094 |
| Distal third (antrum and pylorus) | 0.882 (0.713-1.092) | 0.249 | 0.831 (0.664-1.040) | 0.106 |
| Greater curvature | 0.932 (0.661-1.313) | 0.687 | 0.887 (0.625-1.258) | 0.500 |
| Overlapping lesions | 1.314 (1.012-1.705) | 0.040 | 0.808 (0.613-1.065) | 0.130 |
| NOS | 0.985 (0.712-1.362) | 0.927 | 0.870 (0.623-1.215) | 0.413 |
| Grade | ||||
| Moderately differentiated (II) | 1 | |||
| Poorly differentiated (III) | 1.230 (0.695-2.178) | 0.477 | ||
| Undifferentiated (IV) | 1.362 (0.701-2.645) | 0.362 | ||
| T stage | ||||
| T1 | 1 | 1 | ||
| T2 | 2.624 (1.598-4.310) | <0.001 | 2.562 (1.534-4.278) | <0.001 |
| T3 | 5.877 (3.951-8.740) | <0.001 | 4.668 (3.028-7.195) | <0.001 |
| T4 | 11.257 (7.604-16.670) | <0.001 | 7.353 (4.740-11.406) | <0.001 |
| N stage | ||||
| N0 | 1 | 1 | ||
| N1 | 2.189 (1.678-2.854) | <0.001 | 1.327 (1.001-1.759) | 0.049 |
| N2 | 2.689 (2.091-3.458) | <0.001 | 1.528 (1.166-2.002) | 0.002 |
| N3 | 4.496 (3.580-5.647) | <0.001 | 1.724 (1.312-2.265) | <0.001 |
| M stage | ||||
| M0 | 1 | 1 | ||
| M1 | 3.547 (2.958-4.254) | <0.001 | 2.113 (1.746-2.557) | <0.001 |
| Tumor size (cm) | ||||
| ≤5 | 1 | 1 | ||
| >5 | 2.338 (2.010-2.720) | <0.001 | 1.276 (1.082-1.504) | 0.004 |
| PLNE | ||||
| <15 | 1 | 1 | ||
| ≥15 | 2.800 (2.335-3.357) | <0.001 | 1.418 (1.135-1.771) | 0.002 |
| Radiation | ||||
| No/unknown | 1 | |||
| Yes | 0.909 (0.784-1.055) | 0.211 | ||
| Chemotherapy | ||||
| No/unknown | 1 | 1 | ||
| Yes | 1.399 (1.176-1.666) | <0.001 | 0.669 (0.555-0.807) | <0.001 |
| Year of diagnose | 0.964 (0.942-0.987) | 0.002 | 1.000 (0.976-1.025) | 0.987 |
HR: hazard ratio; CI: confidence interval; PLNE: number of positive lymph nodes.