Table 3.
Validity between the K-ADI-R and the clinical best estimate diagnosis
| Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Cohen’s Kappa (p-value) | |
|---|---|---|---|---|---|
| ASD (N=825) vs. non-ASD (N=446) | |||||
| ADI-R† | 99.27 (98.42–99.73) | 84.75 (81.08–87.96) | 92.33 (90.63–93.75) | 98.44 (96.59–99.29) | 0.868 (<0.001) |
| ADI-R‡ | 86.06 (83.51–88.35) | 99.55 (98.39–99.95) | 99.72 (98.89–99.93) | 79.43 (76.52–82.06) | 0.809 (<0.001) |
| ASD (N=825) vs. OD (N=54) | |||||
| ADI-R† | 99.27 (98.42–99.73) | 59.26 (45.03–72.43) | 97.38 (96.43–98.09) | 84.21 (69.99–92.42) | 0.679 (<0.001) |
| ADI-R‡ | 86.06 (83.51–88.35) | 98.15 (90.11–99.95) | 99.86 (99.03–99.98) | 31.55 (27.93–35.41) | 0.424 (<0.001) |
†
K-ADI-R ASD group defined as participants who equaled or exceeded the cut-off score in at least one domain,
‡
K-ADI-R ASD group defined as participants who equaled or exceeded the cut-off score in all four domains.
ADI-R: Autism Diagnostic Interview-Revised, PPV: positive predictive value, NPV: negative predictive value