TABLE 3.

Performance of the domain scores and the overall scores automatically generated from the bi-factor model in predicting the existing box scores and CDR global

							Classification accuracy**
		VUS or AUC	95% CI		Cutoff	Cutoff	Box score
					1	2	0	0.5	≥ 1	Overall
Community Affairs	mean	0.82	0.76	0.89	0.15	0.86	0.85	0.75	0.8	0.81
	SD	0.03			0.09	0.09	0.04	0.05	0.07	0.03
Judgment and Problem Solving	mean	0.87	0.82	0.92	−0.07	0.65	0.86	0.79	0.83	0.83
	SD	0.02			0.04	0.04	0.03	0.06	0.03	0.02
Memory	mean	0.91	0.87	0.95	−0.16	0.56	0.89	0.84	0.87	0.87
	SD	0.01			0.05	0.05	0.03	0.03	0.03	0.02
Orientation	mean	0.85	0.8	0.91	0.04	0.72	0.85	0.83	0.81	0.83
	SD	0.02			0.03	0.04	0.03	0.04	0.05	0.02
Personal Care*	mean	0.96	0.97	0.99	0.63		0.91		0.96	0.92
	SD	0.02			0.13		0.06		0.04	0.05
CDR global	mean	0.94	0.91	0.96	−0.13	0.7	0.91	0.85	0.91	0.89
	SD	0.01			0.04	0.06	0.02	0.04	0.02	0.02

^*Personal Care domain doesn’t have box score of 0.5.

^**Detailed three by three classification tables (two by two for Personal Care domain) are presented in Table S7 in supporting information.

Abbreviations: AUC, area under the curve; CI, confidence interval; SD, standard deviation of estimates from the 10-fold cross-validation; VUS, volume under the surface.