TABLE 3.

APOE alleles association with neurocognitive function in the SOL‐INCA by background groups (additive inheritance mode)

		Cuban (n = 875)		Dominican (n = 424)		Mexican (n = 1411)		Puerto Rican (n = 734)		South American (n = 313)		Central American (n = 417)
Trait	APOE allele	OR [95% CI]	P‐value	OR [95% CI]	P‐value	OR [95% CI]	P‐value	OR [95% CI]	P‐value	OR [95% CI]	P‐value	OR [95% CI]	P‐value
Significant cognitive decline	2	1.20 [0.80;1.80]	3.96E‐01	0.98 [0.62;1.55]	9.46E‐01	1.03 [0.69;1.54]	8.79E‐01	1.06 [0.69;1.62]	7.95E‐01	1.93 [1.03;3.62]	7.17E‐02	0.65 [0.30;1.38]	3.07E‐01
	4	1.46 [1.13;1.88]	7.00E‐03	0.95 [0.70;1.30]	7.69E‐01	1.05 [0.77;1.43]	7.69E‐01	1.04 [0.84;1.29]	7.31E‐01	0.91 [0.55;1.50]	7.39E‐01	1.05 [0.76;1.46]	7.71E‐01
MCI	2	0.98 [0.49;1.96]	9.54E‐01	1.05 [0.40;2.72]	9.33E‐01	0.54 [0.23;1.29]	2.19E‐01	0.37 [0.16;0.84]	4.41E‐02	0.74 [0.14;3.87]	7.85E‐01	0.34 [0.05;2.19]	3.23E‐01
	4	0.80 [0.42;1.53]	5.26E‐01	0.98 [0.55;1.72]	9.43E‐01	0.90 [0.58;1.38]	6.64E‐01	1.04 [0.65;1.67]	8.64E‐01	0.83 [0.39;1.76]	6.90E‐01	1.08 [0.58;2.01]	8.34E‐01

Notes: Models adjusted for sex, age, education, center, and first five PCs. Effect sizes and SEs were estimated based on the complex survey design method, and were used to compute ORs and 95% CIs. APOE ε3 used as the reference allele. OR values larger than 1 represent decreased neurocognitive function. P‐values were estimated based on 10,000 permutations for each genetic background group. Heterogeneity P‐values were not significant.

Abbreviations: APOE, apolipoprotein E; CI, confidence interval; MCI, mild cognitive impairment; OR, odds ratio; PC, principal component; SOL‐INCA, Study of Latinos‐Investigation of Neurocognitive Aging; SE, standard error.