TABLE 4.
The interaction effect of proportion ancestry and APOE alleles on neurocognitive function in the SOL‐INCA (additive inheritance mode)
| Europe | Africa | Amerindian | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interaction | APOE allele | Interaction | APOE allele | Interaction | APOE allele | ||||||||
| Trait | APOE allele | OR [95% CI] | P‐value | OR [95% CI] | P‐value | OR [95% CI] | P‐value | OR [95% CI] | P‐value | OR [95% CI] | P‐value | OR [95% CI] | P‐value |
| Significant cognitive decline | 2 | 1.76 [0.70;4.40] | 2.41E‐01 | 0.77 [0.42;1.40] | 4.06E‐01 | 0.60 [0.22;1.61] | 3.22E‐01 | 1.23 [0.90;1.67] | 2.03E‐01 | 1.14 [0.32;4.05] | 8.43E‐01 | 1.08 [0.79;1.46] | 6.48E‐01 |
| 4 | 1.58 [0.82;3.06] | 1.90E‐01 | 0.88 [0.58;1.33] | 5.47E‐01 | 1.20 [0.64;2.28] | 5.77E‐01 | 1.11 [0.93;1.34] | 2.63E‐01 | 0.47 [0.24;0.93] | 3.83E‐02 | 1.34 [1.11;1.63] | 3.70E‐03 | |
| MCI | 2 | 0.47 [0.05;4.71] | 5.50E‐01 | 1.20 [0.30;4.83] | 8.12E‐01 | 4.63 [0.66;32.36] | 1.57E‐01 | 0.49 [0.24;1.01] | 6.84E‐02 | 0.03 [0.00;1.38] | 1.07E‐01 | 1.16 [0.60;2.25] | 6.70E‐01 |
| 4 | 1.37 [0.38;4.92] | 6.59E‐01 | 0.81 [0.36;1.85] | 6.39E‐01 | 0.76 [0.16;3.68] | 7.50E‐01 | 1.05 [0.72;1.52] | 8.26E‐01 | 1.01 [0.34;3.01] | 9.92E‐01 | 0.99 [0.66;1.50] | 9.72E‐01 | |
Notes: Models adjusted for sex, age, education, center, and first five PCs. Effect sizes and SEs were estimated based on the complex survey design method and were used to compute ORs and 95% CIs. APOE ε3 used as the reference allele. Interaction P‐values were estimated based on 10,000 permutations for each ancestry separately. OR values larger than 1 represent decreased neurocognitive function.
Abbreviations: APOE, apolipoprotein E; CI, confidence interval; MCI, mild cognitive impairment; OR, odds ratio; PC, principal component; SOL‐INCA, Study of Latinos‐Investigation of Neurocognitive Aging.