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. 2021 Apr 1;11:7335. doi: 10.1038/s41598-021-86818-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decision curve analysis of eight pre- and early-pregnancy significant independent factors in predicting gestational diabetes mellitus later. GDM gestational diabetes mellitus. The orange solid line corresponds to the basic model that includes age, alcohol drinking, cigarette smoking, education, age at menarche, maternal family histories of diabetes mellitus and hypertension, as well as the presence of hemopathy, epilepsy, hyperthyroidism, cardiovascular diseases, liver diseases, kidney diseases, and lung diseases. The green solid line corresponds to the full model that includes both factors in the basic model and the eight newly-identified unrelated significant factors, including pre-pregnancy body mass index, pre-pregnancy intake of folic acid, white cell count, platelet count, alanine transaminase, albumin, direct bilirubin, and creatinine. Over threshold probabilities of 0.2, the net benefit gained by adding the eight significant factors was greater than that in the basic model.